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Knut Schmidt-Nielsen (September 24, 1915-January 25, 2007) was a prominent figure in the field of comparative physiology.

Born in Trondheim, Norway, Schmidt-Nielsen moved to the United States, where he studied at Swarthmore College, Stanford University, and University of Cincinnati College of Medicine. Schmidt-Nielsen published over 275 scientific papers, received the International Prize for Biology, and authored an authoritative text on animal physiology; Schmidt-Nielsen is widely recognized as having made significant contributions to ecophysiology, as well as considered "the father of comparative physiology and integrative biology"Science, 9 February 2007, p.745. Schmidt-Nielsen was James B. Duke Professor Emeritus in the Department of Biology at Duke University and a member of the United States National Academy of Sciences.

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